Magnesium For Nerveneuropathy

The One Essential Mineral For Nerve Growth

Researchers have found magnesium supplements have actually aided in regrowing damaged nerve cells.

They performed scientific tests where mice were split into three groups and fed low, normal or high-magnesium diets.

The mice given food with magnesium supplements displayed marked improvement in

  • neurobehavioral abilities
  • electrophysiological functions
  • enhanced signs of nerve regeneration
  • reduced deposits of inflammatory cells
  • less Schwann cell loss (the material that insulates nerve fibers)

Listen also to the story of Dr. Herbert Mansmann Jr. who was a diabetic with severe peripheral neuropathy.

He was able to reverse the neuropathy and nerve degeneration with a year of using oral magnesium preparations at very high doses.

“For example it took me 6 tabs of each of the following every 4 hours, Maginex, MgOxide, Mag-Tab SR and Magonate to get in positive Mg balance.

I tell people this not to scare them, but to illustrate how much I needed to saturate myself. Most will only need 10% of this amount (still about three grams).

I was doing an experiment on myself to see if it helped my diabetic neuropathy.

It worked so I did it for one year, and I have had significant nerve regeneration.”

massage with magnesium oilBesides taking magnesium supplements orally, a heavenly massage with magnesium oil can supply the body with the needed amount of the mineral by absorbing it through the skin.

Most people do not even know they are magnesium deficient until the shocking facts about how our foods are robbed of magnesium and much of what we eat can delete our bodies’ supply of this vital mineral.

Some of the causes are:

  • Lack of magnesium-rich foods, such as dark green  vegetables, peas, beans, nuts, seeds, halibut, scallops, oysters and tofu in our diets
  • Drinking, purified mineral-free water from bottles
  • Some diuretics lower magnesium levels
  • The antibiotic pentamidine removes magnesium via the urinary system
  • Alcohol in large quantities causes a scarcity of magnesium in the body
  • Even excessive amounts of  fluoride will deplete this mineral

It’s no wonder that the modern eating and medication lifestyle can lead the body into a magnesium-starved condition.

Finally a Japanese study on 1990 hinted that low calcium/magnesium intake with excess amounts of aluminum  and manganese are associated with the incidence of amyotrophic  lateral sclerosis (ALS).

Two Japanese reports of ALS showed significantly higher concentrations of  aluminum in the CNS and in 6 other cases of ALS patients compared with 5 neurologically normal people, it was found that aluminum concentrations in the  precentral gyrus, internal capsule, crus cerebri and spinal cord were significantly higher in the ALS patients compared to the controls.

Meanwhile magnesium concentrations in 26  central nervous system regions were markedly reduced in the ALS  cases and the calcium/magnesium ratios were significantly increased in  ALS patients.

New Test For Diabetic Peripheral Neuropathy

NeuroMetrix recently introduced the NC-stat DPNCheck, which helps diabetics in the early detection, confirmation, and monitoring of diabetic peripheral neuropathy(DPN).

foot stepping on pinsDPN affects over 50% of people with diabetes and causes significant morbidity including pain, increased risk of falling, and is the primary trigger for diabetic foot ulcers which may require lower extremity amputations.

To prevent such serious complications by early detection, DPNCheck measures the standard biomarkers for DPN such as sural nerve conduction velocity and amplitude  in a cost-effective manner at the point-of-care.

Physicians often under-diagnose diabetic peripheral neuropathy, leading to missed opportunities to intervene at an early enough stage to control the damage.

The American Diabetes Association (ADA) recommends diabetics to have annual screening and monitoring for possible DPN.

Currently the most widely used DPN detection tool is the 5.07/10g monofilament, which only identifies late stage neuropathy.

NC-stat | DPNCheck offers:

  • Fast, accurate and quantitative test that may be used to evaluate systemic neuropathies such as DPN
  • May aid in the early detection, confirmation, and monitoring of DPN
  • Measures sural nerve conduction velocity and response amplitude – standard biomarkers for asymptomatic and
    clinical DPN
  • Sensitive and specific for DPN, and predictive of its complications
  • Straightforward clinical interpretation
  • Compact and ergonomic hand-held device designed for ease-of-use
  • Single patient use biosensors
  • Cost effective

For more information go the NeuroMatrix website.


Colostronin may useful in treating neurodegenerative diseases characterized by an overactive immune system, such as nerve neuropathy.

colorful colostrumColostrinin’s potential as a cognitive enhancer is already well-known.

Colostrum, the first milk produced by a mother after her child is born, is a rich source of beneficial components, including immunological factors, anti-inflammatory factors, gastrointestinal health factors, growth factors, antioxidant and anti-aging factors.

As colostrum is mother’s milk, the first meal a baby has in this world, it is a natural product without the dangerous side effects common to artificial pharmaceuticals, and has been used for thousands of years for its health-promoting benefits.

Derived from colostrum, which is present in the pre-milk fluid produced from mammary glands in the first few days after parturition, colostrinin is a member of the proline-rich polypeptide family.

PRPs immunological function relate to their ability to modulate and stabilize many biological processes in the body including cytokine and immune activity.

The immune-modulating factor makes colostronin effective in treating diseases such nerve neuropathy, because it suppresses over-active immune systems that attack the fatty coverings of nerve fibers.

High-Cost Neuropathy Screening

Are you paying too much for neuropathy screening?

medical hammer tapResearchers at the University of Michigan found that less expensive, more effective tests are less likely to be used than the costlier ones.

Almost one-quarter of patients receiving neuropathy diagnoses undergo high-cost, low-yield MRIs while very few receive low-cost, high-yield glucose tolerance tests, according to the study that will be published Jan. 23 in the Archives of Internal Medicine.

“Patients diagnosed with peripheral neuropathy typically are given many tests but physicians are highly variable in their approach. Neurologists spend a lot of money to work up a diagnosis of neuropathy. The question is whether that money is well spent,” lead researcher Callaghan says.

For patients with peripheral neuropathy, the nerves that carry information to and from the brain don’t work property. This commonly leads to tingling or burning in arms or legs and loss of feeling — and the symptoms can go from subtle to severe.

Diabetes is the most common cause of this type of nerve problem. Peripheral neuropathy is found in about 15 percent of those over age 40.

Researchers used the 1996-2007 Health and Retirement Study to identify individuals with a diagnosis of peripheral neuropathy, focusing  on 15 relevant tests and examined the number and patterns of tests six months before and after the initial diagnosis.

“Our findings, that MRIs were frequently ordered by physicians, but a lower-cost glucose tolerance test was rarely ordered, show that there is substantial opportunity to improve efficiency in the evaluation of peripheral neuropathy,” Callaghan says.

“Currently no standard approach to the evaluation of peripheral neuropathy exists. Many tests cost a lot of money, but there is common agreement on evaluations.”

“The climbing rates of diabetes in the U.S. make this research even more important,” says co-author Kenneth M. Langa, M.D., Ph.D., a professor of Internal Medicine at U-M.

“We know more and more people may develop peripheral neuropathy because it is commonly caused by diabetes. Our study suggests that the work-up currently used for neuropathy isn’t standardized and tests that are less useful and more expensive may be used too often,” says Langa. “We need a more efficient way to handle this increasingly common diagnosis.”

Journal reference: Arch Intern Med. 2012; 172[2]:127-132.

Proteomics For Nerve Regeneration

Proteomics, which is the large-scale study of proteins, is considered the next step in the study of biological systems.

proteomics lab techniquesProteomics is much more complicated than genomics because while an organism’s genome is more or less constant, the proteome differs from cell to cell and from time to time.

A chapter in the recent book, Neuroproteomics, focuses on how proteomics may help in nerve cell regeneration from peripheral nerve injury, or maybe even nerve neuropathy.

The author, M.W. Massing et al, describes how pervasive nerve injury is in our society.

“Although a common and increasingly prevalent wartime condition, injury to peripheral nerves, plexuses, and roots is present in 5% of patients seen in civilian trauma centers.

In one study, almost half of peripheral nerve injuries at trauma centers were due to motor vehicle accidents and about half required surgery.

Peripheral nerve injuries can substantially impact quality of life through loss of function and increased risk of secondary disabilities from falls, fractures, and other injuries.”

He continues on to stress the importance of lipid-rich Schwann cells in nerve cell regeneration:

“The primary supporting cell for peripheral nerves is the Schwann cell.

Schwann cells wrap around axons in a spiral fashion multiple times and their plasma membranes form a lipid-rich tubular cover around the axon known as the myelin sheath or the neurilemma.

Schwann cells and the myelin sheath support and maintain axons and help to guide axons during axonal regenerationfollowing nerve injury.”

This raises the controversy about the relationship between Lipitor and nerve neuropathy.

Later the author reveals the main obstacle to nerve regeneration lies not growing myelin sheath, making the right connections:

“The major key to recovery of function following peripheral nerve lesions is the accurate regeneration of axons to their original target end organs.

A recognized leader of clinical nerve repair once stated, ‘The core of the problem is not promoting axon regeneration, but in getting them back to where they belong.'”

Simply stated, perhaps there is hope that nerve neuropathy can be treated when researchers can overcome the very challenging barriers.

Paolo Zamboni with MMN

Progressing slowly in the hallway Arcispedale Sant’Anna, the feet of ballasted orthopedic boots resound in the hallways.

He hands me both hands, unable to close but still able to transmit the heat of empathy.

chemistry of MMNProfessor Paolo Zamboni, director of vascular diseases and professor of clinical methodology of the University of Ferrara, has a rare medical illness.

He has been stricken, “Experts do not know how, or do not know why,” with a disease not often encountered, probably from the immune system, which weakens the nerves and muscles.

It’s called MMN or technically multi-focal motor neuropathy.

“So far we have surveyed only a thousand cases between Europe and the United States. It is a mild form of ALS, amyotrophic lateral sclerosis.”

But it’s against another MS, the multiple (the acronym, MS), which Professor Zamboni has fought and won the hardest battle of his life.

Wanting at all costs to heal his wife Helen, who had been hit, he did the logical thing for a scientist: “I tried to understand.”

The end point was the discovery of CCSVI, an acronym that made ​​him famous in the world, so much so that now:

  • His surgery is booked until Easter
  • The switchboard of the study was replaced by a recorded voice that invites you to recall better times
  • The computer department of the hospital has accumulated 24,000 emails asking for medical examinations which he can not cope
  • A Facebook group titled “Dr. Nobel Prize for Paolo Zamboni” has already gathered 7,957 supporters who would like to apply for the prize for medicine awarded by the Karolinska Institutet
  • Marco Marozzi has devoted a fascinating book of 334 pages, “Brave Dreams? (Knopf), which tells precisely “the struggle of a Italian doctor battling multiple sclerosis.”

(read more)

Alcoholic Neuropathy

Up to half of all long-term heavy alcohol users develop alcoholic neuropathy.

martini glass with olives

Alcoholism tied to neuropathy

Alcoholism makes the body unable to use or store certain vitamins and minerals such as thiamine (vitamin B1), pyridoxine (vitamin B6), pantothenic acid and biotin, vitamin B12, folic acid, niacin (vitamin B3) and vitamin A.

Damage to nerves from alcoholic neuropathy is usually permanent and may get worse with continued consumption of excessive amounts of alcohol.

The neuropathic signs of alcohol abuse vary from mild discomfort to severe disability, which can lead to emotional, physical and monetary disasters affecting not only the sufferer but loved ones also.

What to do?

In addition to abstinence from binge drinking, a supplemental vitamin enhancement program, especially B1 is recommended, although the results depend on the severity of the damage.

If the symptoms are caught early enough, the body may be able to normalize itself to its previous state.

However in most cases, scientific studies indicate the effects are permanent, but not life-threatening and the patient adapt to the new reality.


Toasted Bread and Neuropathy

Eating too much toasted bread and french fries may lead to neuropathy.

slice of toasted breadFoods prepared at high temperatures via frying, grilling or toasting can result in the formation of a substance called acrylamide and scientific studies have proven that long-term exposure to small doses of acrylamide causes nerve damage in the extremities.

Potential symptoms of overexposure to acrylamide include numbness of the limbs, and weakness with lack of coordination in the legs.

Since high temperatures and starchy foods are necessary to form this neurotoxin, the good news is that diets low in fried starchy foods contain very low levels of acrylamide.

Food choice and acrylamide exposure

  • Acrylamide has been found primarily in food made from plants, such as potatoes, grain products, and coffee. Acrylamide is not typically associated with meat, dairy, or seafood products.
  • Acrylamide is typically found in plant-based foods cooked with high heat (e.g., frying, roasting, and baking), not raw plant-based foods or foods cooked by steaming or boiling.
  • Some foods are larger sources of acrylamide in the diet, including certain potato products (especially French fries and potato chips), coffee, and foods made of grains (such as breakfast cereal, cookies, and toast).

There are a couple of nutritional supplements that are believed to offer protection against acrylamide’s toxicity:

One study indicated N-acetyl-cysteine and lipoic acid have been shown to be protective against acrylamide’s toxic effects and offer a dietary means of counteracting acrylamide’s bad effects.

Another study showed that acrylamide’s neurotoxicity was due to a dramatic reduction in glucose metabolism in nerve cells, and that lipoic acid could help prevent this negative effect and help restore normal metabolism and prevent damage.

IVIG Headache

In the literature headaches seem to go together with IVIG treatments.

woman suffering from headacheAfter 3 years of 30 grams of IVIG infusions every three weeks at home, for my multi-focal motor neuropathy condition, I have never experienced a headache, or other side effects, due to the IVIG treatment.

The one factor that I religiously follow is to lie prone during the IVIG infusion. I never, ever sit up during the procedure.

Most of the time I try to sleep during the 3 hour IVIG drip session and stay completely calm.

The body is getting an extreme shock due to pumping in what it senses as a foreign substance, so it is extremely important to relax the body and tell it everything is okay.

Other medications may interact with the IVIG chemicals, so check to see if other drugs you are taking may be causing the IVIG to give you the severe headaches.

Cell Phone Elbow

Holding a cell phone for long times with a bent elbow can lead to a condition called “cell-phone elbow,” but scientifically known as cubital tunnel syndrome.

man in suit looking at cell phoneVictims often experience numbness and tingling along the little finger and part of the ring finger. The effects can even lead to weakness of grip and, rarely, wasting of the hand muscles.

Technically cubital tunnel syndrome is defined as a chronic neuropathy (“nerve disease”) of the ulnar nerve, which results in a sensory, motor or mixed neuropathy. Most commonly seen in adults, it affects twice as many men as women.

Only a qualified physician can diagnose this disorder, but do seek medical advice because in some extreme cases surgery may be needed to correct it.

Simply switching the arm holding the cell phone or using a hands-free Bluetooth earpiece will help prevent undue stress on the elbow.

For more details on the cell-phone syndrome, refer to the article by Dr. Peter J. Evans.