L-arginine supplements for neuropathy

jogger autumn afternoon city setting

As a supplement L-arginine may be useful in certain cases, although the data is doesn’t say L-arginine is a cure.

Doctor Joe discusses diabetic peripheral neuropathy and the role of L-arginine.


Mayo Clinic opinion on L-arginine

“The below doses are based on scientific research, publications, traditional use, or expert opinion. Many herbs and supplements have not been thoroughly tested, and safety and effectiveness may not be proven.

“For diabetic complications (peripheral neuropathy), 3 grams of L-arginine has been taken by mouth three times. A cream containing 4 milligrams of L-arginine per square centimeter has been applied to the feet in the morning and evening daily for two weeks.”

A study in 2010 from England found L-arginine to be ineffective treating diabetic foot neuropathy.

Effect of L-arginine on the microcirculation in the neuropathic diabetic foot in Type 2 diabetes mellitus

“L-arginine has no effect on endothelial dysfunction, foot transcutaneous oxygen pressure, and clinical neuropathy.”

Next Step Foot and Ankle Clinic recommends L-arginine in treating neuropathy.

Research paper from France shows promise for L-arginine treatment in laboratory animals.

L-Arginine supplementation prevents allodynia and hyperalgesia in painful diabetic neuropathic rats…

“L-Arginine supplementation prevented the development of mechanical hyperalgesia, tactile, and thermal allodynia in painful diabetic neuropathy with concomitant reduction of NO and increased agmatine production, offering new therapeutic opportunities for the management of diabetic neuropathic pain.”